Algorithm-controlled focused ultrasound system uses microbubbles to open a pathway for a powerful immunotherapy to reach brain tumors
Associate Professor Costas Arvanitis and mechanical engineering Ph.D. student Hohyun "Henry" Lee with their closed-loop controlled focused ultrasound system. The system uses ultrasound-induced microbubbles to help a powerful immunotherapy target brain tumors and a custom algorithm to continuously fine tune the bubbles for maximum impact. (Photo: Candler Hobbs)
“Closing the loop” has become one of the jargony cliches of the business world. But in the world of cancer immunotherapy, closing the loop could be an innovation that unlocks powerful therapies for hard-to-treat brain cancers called glioblastomas.
Researchers at Georgia Tech and Emory University have developed a system that uses ultrasound-induced microbubbles to help a powerful immunotherapy target brain tumors and a custom algorithm to continuously fine tune the bubbles for maximum impact.
Their closed-loop controlled focused ultrasound system proved effective in boosting survival rates in mouse models, including eradicating the entire tumor in at least one case. They described their approach Nov. 18 in the journal Science Advances.
Latest BME News
Coskun pioneering new research area and building a company around iseqPLA technology
BME researcher Ankur Singh using new technology to uncover weakened response in cancer patients
Research team led by BME's Cheng Zhu probes the underlying mechanisms of PD-1 checkpoint inhibitor therapy
Georgia Tech grad reflects on his rookie season as a biomechanics engineer with the New York Mets
First-year students learned about the resources and support they could access during their college journey in BME.
BME assistant professor using Sloan Scholars Mentoring Network seed grant to support her lab's work
Coulter Department honors Jaydev Desai, Melissa Kemp, Gabe Kwong, and Johnna Temenoff