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Finding the Driving Forces Behind Cancer Metastasis
Posted October 20, 2023

 

Denis Tsygankov, associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, is part of a research team exploring the driving forces behind cancer metastasis.

 

When cancer cells metastasize, breaking away from the original tumor, they embark on a long-range trek, efficiently navigating a series of complex, crowded, and confined microenvironments before putting down toxic roots in another location. 

It’s an aggressive, all-out cellular assault on the body, taking a ruinous toll on patients. Because while most metastatic cancers are manageable to some extent, they’re usually not curable. 

But a new multi-institutional study focused on the mechanisms underlying this destructive cancer cell exodus, co-led by Georgia Tech/Emory researcher Denis Tsygankov, may offer hope to these patients. Published in the journal Advanced Science, the research team identifies the motor protein dynein as a driving force of metastasis, beyond its well-known role in intracellular trafficking.

“The team demonstrated that high expression of dynein in cancer patients strongly correlates with metastatic aggressiveness," said Tsygankov, associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

The dissemination of cancer cells through the body has been mostly linked to actomyosin-driven cell locomotion. But metastasis does not always line up so neatly with the forces resulting from actomyosin contractility. Indeed, in highly confined environments, actomyosin activity is reduced, allowing cells to change shape and squeeze through tight spaces in the extracellular matrix or between neighboring cells. 

On the other hand, the study results indicate that dynein becomes indispensable under such conditions, playing a complementary force-generating role to actomyosin in migration through complex environments, such as during metastasis.

Tsygankov is one of three corresponding authors of the study, with Erdem Tabdanov (project lead) and Amir Sheikhi, both of Penn State University. Their collaborators included researchers from the University of Rochester and the U.S. Food and Drug Administration.

The project brings together multiple disciplines like cellular biomechanics (Tabdanov), bio-soft materials (Sheikhi), with the Tsygankov lab’s expertise in computational methods, including mathematical modeling and computer vision. For this study, his team developed a novel automated method for efficient identification and tracking of cells with complex dynamic shapes in label-free microscopy.

“With this research we’ve advanced our fundamental understanding of the molecular mechanisms of cell locomotion and identified an underappreciated role of dynein in this process,” Tsygankov said. “This opens up an opportunity for discovering new therapeutic strategies to fight aggressive metastasis.”

Citation: Yerbol TagaySina KheirabadiZaman AtaieRakesh K. SinghOlivia PrinceAshley NguyenAlexander S. ZhovmerXuefei MaAmir SheikhiDenis TsygankovErdem D. Tabdanov. “Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer,” Advanced Sciencedoi.org/10.1002/advs.202302229

 

A multi-institutional team led by (left to right) Denis Tsygankov, Erdem Tabdanov, and Amir Sheikhi has discovered a new role for the protein dynein, as a driving force in cancer metastasis.

 

Contact

Jerry Grillo
Communications
Wallace H. Coulter Department of Biomedical Engineering

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Both the graduate and undergraduate programs in the Wallace H. Coulter Department of Biomedical Engineering were nationally ranked no. 1 in 2023. It was a first-time top ranking for the grad program. Dedicated faculty and innovative curriculum earned the department its lofty spot and will be what keeps it there in the future.