The goal of our laboratory is to design polymeric biomaterials for specific orthopaedic applications, including regeneration of tendon/ligament, cartilage and bone. These synthetic and naturally-derived biomaterials are used in conjunction with other biochemical and mechanical stimuli to promote priming of stem cells to express a particular phenotype, as well as deliver biomolecules to promote healing of tissues that have degenerated due to chronic conditions, such as osteoarthritis or overuse injuries.