My laboratory utilizes proteomics and high-throughput experimental genetics to build mechanistic models of biological functions, and applies this knowledge to invent and refine therapeutic treatments. We are interested in all aspects of human biology, especially questions offering tractable genetic systems, an ample supply of primary tissues, and opportunities to rapidly test therapeutic interventions.
I have a diverse research background spanning cell and molecular biology, experimental genetics, proteomics, virology, and systems biology. As a graduate student at the University of Cambridge I applied combinatorial experimental genetics and proteomics to map redundant vesicle trafficking pathways. Later, as a postdoctoral fellow at the University of California San Francisco, I pioneered the use of high-throughput genetic interaction mapping to study HIV host-dependencies, and spearheaded the first peer-reviewed protein interaction maps of the highly pathogenic coronaviruses SARS-CoV-2, SARS-CoV-1, and MERS. Leveraging academic and industry collaborations, my laboratory builds on lessons learned during these pioneering studies to develop high-throughput experiments in primary systems, to systematically dissect the mechanistic basis of biological function and disease pathology. Our collaborations are highly interdisciplinary and span many biological questions relevant to human health.
Our laboratory location on the Innovation Floor of the new Health Sciences Research Building II (HSRB2) offers close proximity to collaborators focusing on infectious disease, vaccinology, neuroscience, cardiology, and cell therapy. My primary appointment with the Emory University Department of Pathology and Laboratory Medicine enables access to numerous types of primary tissue samples. Adjacent to the CDC, with ample access to BSL facilities, we are located at a nexus of infectious disease research. Our affiliation with the Emory Vaccine Center and the Pathology Translational Research Unit provides extraordinary collaboration opportunities with world-leading immunologists. We are within walking distance to Emory University Hospital and the Yerkes National Primate Center, offering numerous collaborative opportunities in both clinical and animal studies. Lastly, our affiliation with the Coulter Department of Biomedical Engineering and Georgia Tech enables transformative collaborations with world-class innovators in cell therapy and computational biology.